Effect of Paint Exposure Among Paint Workers and DNA Damage: A Scoping Review

@#Paint contains various complex chemical mixtures, such as aliphatic hydrocarbons, aromatic hydrocarbons (primarily toluene), ketones, and benzene as reported at previous studies. Toxicity from some chemicals can cause early DNA damage with various factors. A scoping review was conducted via literature review on relevant studies on the effect of paint exposure on paint workers and DNA damage. A systematic search was conducted in October 2021 via PubMed, Scopus, and Web of Science databases. The key terms used were paint, solvent-based paint, organic solvent, mixed organic solvent, occupational exposure and DNA damage, oxidative stress, genotoxicity on a painter, paint worker. From 561 articles, only 13 articles were finally selected based on the inclusion, exclusion criteria, and eligibility criteria. The literature showed that biomonitoring studies on painters were consistently reporting positive and significant DNA damage due to exposure to different types of compounds mixed in a paint. However, there were fewer studies on paint manufacturing factory workers compared to painters while paint manufacturing workers exposed various chemical everyday during the paint production which potentially susceptible to occupational toxicity. In conclusion, this review suggests that exposure to paints could induce early DNA damage among paint workers and further investigations on paint exposure among paint manufacturing factory workers and the DNA damage were needed in order to improve occupational health among paint workers in the future.

The Determinants of Undiagnosed Hypertension Among Indonesian Adults: A Cross-sectional Study Based on the 2014-2015 Indonesia Family Life Survey / 예방의학회지

Objectives@#This study investigated the determinants of undiagnosed hypertension among Indonesian adults. @*Methods@#This study involved an analysis of secondary data from the 2014 Indonesia Family Life Survey (IFLS) on 5914 Indonesian adults (≥40 years). The determinant variables examined in this cross-sectional study were education level, monthly per capita expenditures (PCE), whether the participant experienced headaches in the morning, and other general health variables. The outcome variable was undiagnosed hypertension, which was defined as participants with hypertension who had not received a hypertension diagnosis from a health professional and had never been prescribed medication for treating hypertension. The data were analyzed using logistic regression. @*Results@#A total of 3322 participants (56.2%) were found to have undiagnosed hypertension. The odds ratios (ORs) and 95% confidence intervals (CIs) of undiagnosed hypertension were significantly higher among those who completed primary school or lower (OR, 1.60; 95% CI, 1.29 to 1.98), had low monthly PCE (OR, 1.28; 95% CI, 1.13 to 1.43), did not report experiencing headaches in the morning (OR, 1.97; 95% CI, 1.76 to 2.21), and reported a general health status of healthy (OR, 2.05; 95% CI, 1.82 to 2.30) than those who had a higher education level, had high monthly PCE, experienced headaches in the morning, and were unhealthy. @*Conclusions@#Education level, monthly PCE, the experience of headaches in the morning, and general health status were associated with undiagnosed hypertension. The monitoring system for detecting undiagnosed hypertension cases must be strengthened. Health promotion is also necessary to reduce the prevalence of undiagnosed hypertension.

Extraperitoneal cesarean section: a retrospective analysis

Background: Morbidity of caesarean section still persist in terms of pain, infection and adhesion. This study will focus on different morbidities associated with ECS.Methods: A retrospective analysis of 29 ECS were included from June to September 2018, done at Midnapore Medical college, West Bengal, India.Results: Contracted pelvis (12/29, 41.37%) and cephalopelvic disproportion (10/29,34.48%) were common indications for ECS. Mean gestational age was 39.65±1.31 weeks and birth weight were 3.01±0.40 kg. Time taken for ECS was 33.06±10.85 minutes. Extension of uterine incision and mild distension of abdomen occurred in 3.44% each. Post-operative period was uneventful and all discharged after 72 hours of operation.Conclusions: ECS can be performed safely by experienced hands with less feto-maternal morbidity and early discharge of mother and baby.

Development patterns of necrophagous flies infesting rabbit carcasses decomposing in Mount Kapur Cave and its surrounding primary forest in Kuching, Sarawak

@#In addition to the scarcity of forensic entomology baseline data on oviposition of necrophagous insects and completion of their life cycles in the Borneo region, similar data derived from caves remain unreported. Since entomological baseline data can differ from one biogeoclimatic region to another, the lack of such data would limit the practical values of applying entomological evidence in estimating minimum postmortem interval (mPMI). Therefore, this present research that investigated oviposition and completion of life cycles of necrophagous flies infesting rabbit carcasses decomposing in Mount Kapur Cave and its surrounding forest habitat in Kuching, Sarawak merits forensic consideration. In general, 13 taxa of necrophagous flies were identified viz. Hypopygiopsis violacea, Hypopygiopsis fumipennis, Hemipyrellia ligurriens, Hemipyrellia tagaliana, Chrysomya megacephala, Chrysomya villeneuvi, Chrysomya rufifacies, Chrysomya chani, Chrysomya pinguis, Chrysomya nigripes, Ophyra spinigera and Ophyra chalcogaster, as well as unidentified Sarcophagidae. In addition, Hyp. violacea and Hyp. fumipennis were the two earlier necrophagous flies that oviposited in all rabbit carcasses decomposing in both habitats. While all these necrophagous flies were observed infesting carcasses in Mount Kapur Cave, Hem. ligurriens and Hem. tagaliana were not found infesting carcasses in the surrounding forest habitat. Complete life cycles for six and five different necrophagous fly species were successfully observed in Mount Kapur Cave and its surrounding forest habitat, respectively. Significant delay in oviposition, as well as longer durations for completing the life cycles in several necrophagous fly species were observed in Mount Kapur Cave when compared with those of surrounding forest habitat (p < 0.05). These findings deserve consideration as the first ever forensic empirical baseline data on oviposition and completion of life cycles for necrophagous flies in Sarawak as well as in a cave habitat, in view of its practical values for estimating mPMI for forensic practical caseworks.

Oral Health Knowledge, Attitude and Practice of the Caregiver at the Special Needs Boarding School in Kuantan, Pahang

@#Introduction: Caregivers and parents are important to the healthy development of children. Therefore, this study was undertaken to assess the knowledge, attitude and oral health practice among caregivers of children with disabilities. Method: A cross-sectional study was conducted among caregivers in three special boarding schools in Kuantan, Pahang, who cared for 7 to 17 years old disabled children using self-administered questionnaires. Kruskal-Wallis and Chi-square test were used to analyse the data. Results: Most caregivers were female (73.2%). The overall mean knowledge score was 87.75%. All of caregivers have agreed that sugary or sticky food and drinks can cause caries and toothbrushing for children is important for oral health. All of the caregivers possess secondary educational level where 75% of the caregivers with tertiary educational level assist the children while brushing teeth. However, 71.9% of caregivers with tertiary educational level and 45% of caregivers with secondary educational level had shown poor oral health practice since they were frequently giving sweet food to the children. Surprisingly, most of the caregivers with secondary educational level (95.2%) and caregivers with tertiary educational level (85%) thought children with disabilities can brush their teeth independently. Conclusion: Despite having adequate oral health knowledge among the caregivers in the special needs boarding schools, their attitude and oral health practice however were not up to the necessary standards. The implementation of oral health promotion related programmes in the special needs boarding schools must be taken into consideration in order to tackle the oral health problems of children with disabilities.

Psychotherapy For Prison Populations: A Review

@#Introduction: Psychotherapy is a form of treatment intervention targeting problematical human behaviour, emotion, and cognition using various psychological techniques and approaches. In Malaysia, the application of psychotherapy in ameliorating criminality among forensic populations is developing and evidence shows that some therapies like Cognitive-Behavioural Therapy and Reality Therapy have been practiced in many correctional institutions. Objective: This paper aims to review the role of psychotherapy for help in correctional settings as a means to ameliorate criminal behaviour and reduce recidivism rates. Method: An archival research was utilised, where articles and books regardless of the year of publication from different countries, including Malaysia were examined. Several keywords were used for the purpose of retrieval of related articles. Results and Discussion: Three different approaches of psychotherapies, i.e. Behavioural Therapy, Cognitive Therapy and Cognitive-Behavioural Therapy and their principles and effectiveness in rehabilitating the forensic populations were elaborated in this review. The principle behind the effectiveness of the psychotherapy was different, and this influences the choice of treatment that should be used in dealing with the forensic populations. Conclusion: Â Forensic populations have rights to obtain treatment, and the choice of therapy has to be relevant within the context of cost-effectiveness to ensure optimum effectiveness in ameliorating criminal tendencies. Â

Mechanical profiles of murder and murderers: An extensive review

@#Introduction: Murder is an extreme form of violent crime which occurs across all social, cultural, and ethnic spheres. It is therefore, crucial to understand the nature and the extent of mechanical profiles of murder and murderers. The purpose of this article is to review such critical aspects of murder in a nutshell. Methods: An archival research methodology was employed in this study where relevant search for literatures on these mechanical aspects related to murder was made across search engines such as Google Scholar and Elsevier with relevant articles selected for this review. Results and Discussion: This review discusses in an in-depth manner, pivotal mechanical profiles which include motives, methods of killing, choice of weapon, settings, targeted body parts, and murder victim concealment. In-depth understanding of each mechanical aspect offers an opportunity to the public at large to expand their knowledge on murder prevention manners which is vital for crime prevention efforts in the future.

Psychological markers underlying murder weapon profile: a quantitative study

The horrific nature of murder using different types of weapons has been an important focal point ofmany criminological studies. Weapons that are used in murders seem to play dominant roles in murderinvestigations as they may provide information leading to arrest. The established factors for weaponusage include environmental context, demography and availability of weapons. However, there isinsufficient research attention on the psychological functioning of murderers for particular weaponusage. In light of this, the current study seeks to narrow this gap of information by identifying theinfluences of psychological traits on weapon usage among a sample of male murderers. The presentcross-sectional study was conducted among 71 male murderers incarcerated in 11 prisons withinPeninsular Malaysia. The selection of the sample was based on predetermined selection criteriausing a purposive sampling method. A guided self-administered questionnaire comprising sociodemographyvariables and four Malay validated psychometric instruments: Zuckerman-KuhlmanPersonality Questionnaire-40-Cross-Culture, Self-control Scale, “How I Think” Questionnaire andAggression Questionnaire; was used. Independent sample t-test was performed to establish themean score differences of psychological traits between the murderers who used single and multipleweapons while Kruskal-Wallis tests were carried out to ascertain the differences between the specifictypes of weapons used among the murderers. Following this, one-way ANOVA was carried out toascertain the psychological trait differences among the murderers according to the different sourcesof weapon. Results indicated specific psychological traits influenced the number(s), source(s) andtype(s) of weapon used in committing murder. The findings have implications for the psychologicalprofiling of unknown murderers within the Malaysian context.

P16INK4a: A Potential Diagnostic Adjunct For Prediction Of Highgrade Cervical Lesions In Liquid-Based Cytology: With HPV Testing And Histological Correlation

Human papillomavirus (HPV) is a necessary cause of cervical cancer and its precursors. Increased expression of high-risk hrHPV viral oncogenes in abnormal cells might increase the expression of p16INK4a. We aimed to determine the role of p16INK4a in detecting hrHPV-transformed epithelial cells in liquid-based cervical cytology, and compared the results with hrHPV DNA testing by realtime polymerase chain reaction (RT-PCR). Fifty-seven cytological samples were tested for p16INK4a immunomarker and hrHPV DNA. Test performance of both tests was determined by comparing sensitivity, specificity and predictive values using available histological follow-up data as gold standard. Of 57 samples, 36 (63.2%) showed immunoreactivity for p16INK4a and 43 (75.4%) were hrHPV-infected. A fairly low concordance rate (k = 0.504) between p16INK4a immunolabelling and hrHPV DNA status was noted. For prediction of cervical intraepithelial neoplasia (CIN) II and worse lesions, p16INK4a had a sensitivity and specificity of 93.5% and 60%; whereas hrHPV DNA testing had a sensitivity and specificity of 100% and 20%. Dual testing by combining p16INK4a and hrHPV showed sensitivity and specificity of 100% and 33.3%. In conclusion, p16INK4a is useful in predicting severity of the cytological abnormalities. Although p16INK4a is more specific but less sensitive than hrHPV in detecting high-grade cervical lesions, a combination of both tests failed to demonstrate significant improvement in diagnostic sensitivity, specificity and predictive value. Larger-scale prospective studies are required to assess further whether this biomarker should be routinely used as primary screening tool independently or in combination with hrHPV testing to improve diagnostic accuracy in cervical cytology.

The Needs of Malaysian Family Members of Critically Ill Patients Treated in Intensive Care Unit, Hospital Universiti Sains Malaysia

Background: The needs of intensive care patient’s family members are often neglected. Many healthcare practitioners do not realize that meeting the family needs in the intensive care settings actually may improve outcome for their patients and enable the family members to cope and deal with the patient’s hospitalization period effectively. With this in mind, the present study aimed to address the needs of Malaysian family members of intensive care unit patients. Methods: This cross-sectional survey was conducted among family members of Intensive Care Unit of Hospital Universiti Sains Malaysia, Malaysia. A total of 60 family members were recruited using a convenience sampling manner. A Malay validated Critical Care Family Needs Inventory was used to identify the family needs among the respondents. Descriptive statistics as well as mean comparison analyses were employed to achieve the study. Results: The findings showed that family members ranked Assurance items as the most important needs. In terms of subscales scores, Assurance and Information evidenced higher mean scores compared to other dimensions. All the family need dimensions had positive and significant associations with one another. The highest correlation was noted among Comfort – Support pair, r(58) = 0.73, p < 0.001. No significant differences in the mean values found across gender, history of admission and types of relationships. In contrast, significant mean difference was observed across level of education. Conclusion: Identifying the needs of family members in the intensive care unit is imperative as it raises awareness and contributes knowledge in terms of family needs to healthcare providers, policy makers, medical social workers and general public.

Linking Psychological Traits With Criminal Behaviour: A Review

Objective: Apart from environmental and social factors, psychological traits is largely linked with criminal and delinquent behaviour. The purpose of this article is to review four critical psychological traits of individuals that may lead to criminal behaviour in a nutshell. Methods: An archival research methodology was employed in this study where relevant search for literatures on these four psychological traits was made across search engines such as Google Scholar with relevant articles selected for this review. The literatures were microscopically reviewed in order to demonstrate the linkage between psychological traits and criminal behaviour. Results: Four psychological traits: personality trait, low self-control, aggression behaviour, and cognitive distortion were chosen to address such linkages. All these four traits were discussed thoroughly in relation to crime and criminality contexts. Conclusion: It is crucial to understand the role of these traits and in-depth understanding of each psychological trait with relation of criminal behaviour offers and opportunity to the public at large to expand their knowledge on the importance of practicing and equipping oneself with healthy psychological traits to hinder criminal and delinquent acts.

2 Handfuls of Medication in 2 Hours Just to Let Him Talk.

Repeated dose of adrenaline in anaphylaxis is limited evidence in clinical setting. Hence, the usage is depending on physician best interest and knowledge. We reported a case of repeated doses of adrenalin was given through nebulizer and intravenous in anaphylaxis. We believed the unusual circumstances of this case was likely to be repeated on some readers' clinical practice and this mode of treatment is an adjunct to consider in such cases especially in Emergency Department (ED).

Psychological traits underlying different killing methods amongMalaysian male murderers

Murder is the most notorious crime that violates religious, social and cultural norms. Examining the types and number of different killing methods that used are pivotal in a murder case. However, the psychological traits underlying specific and multiple killing methods are still understudied. The present study attempts to fill this gap in knowledge by identifying the underlying psychological traits of different killing methods among Malaysian murderers. The study adapted an observational cross-sectional methodology using a guided self-administered questionnaire for data collection. The sampling frame consisted of 71 Malaysian male murderers from 11 Malaysian prisons who were selected using purposive sampling method. The participants were also asked to provide the types and number of different killing methods used to kill their respective victims. An independent sample t-test was performed to establish the mean score difference of psychological traits between the murderers who used single and multiple types of killing methods. Kruskal-Wallis tests were carried out to ascertain the psychological trait differences between specific types of killing methods. The results suggest that specific psychological traits underlie the type and number of different killing methods used during murder. The majority (88.7%) of murderers used a single method of killing. Multiple methods of killing was evident in ‘premeditated’ murder compared to ‘passion’ murder, and revenge was a common motive. Examples of multiple methods are combinations of stabbing and strangulation or slashing and physical force. An exception was premeditated murder committed with shooting, when it was usually a single method, attributed to the high lethality of firearms. Shooting was also notable when the motive was financial gain or related to drug dealing. Murderers who used multiple killing methods were more aggressive and sadistic than those who used a single killing method. Those who used multiple methods or slashing also displayed a higher level of minimisation traits. Despite its limitations, this study has provided some light on the underlying psychological traits of different killing methods which is useful in the field of criminology.

An investigation of inter-examiner reproducibility in recording malocclusion parameters during orthodontic epidemiologic studies

This study assesses inter-examiner reproducibility in recording various malocclusion parameters and Index of Orthodontic Treatment Need (IOTN) grade during patient examination by utilising the kappa statistic. Five previously calibrated orthodontists clinically examined 233 non-orthodontically treated schoolchildren aged 14-17 years for recording various malocclusion parameters. The examination was repeated twice, thirty days apart and precluded the use of study-models or radiographs. Although good inter-examiner reproducibility was observed in recording incisor class, IOTN dental health grade, type of posterior crossbite, and excellent for parameters with absolute criteria like erupted supernumeraries, etc, substantial examiner variation resulted in only fair reproducibility for recording IOTN esthetic category, canine class, overbite category, traumatic overbite and upper centre-line shift of two millimetres or more from the facial midline. Reproducibility for detecting occlusal displacement in the presence of crossbite was poor, and kappa statistic was incalculable for recording openbite and number of upper incisors rotated 30° or more. Kappa was also incalculable for recording IOTN dental health subcategory due to the creation of asymmetric tables caused by rarely chosen subcategory options. Despite prior agreement between previously calibrated examiners on evaluation criteria, detection of certain malocclusion parameters during an epidemiological examination can prove to be challenging. Epidemiological studies that report on prevalence of malocclusion in the population should always report on the kappa reproducibility, especially if the study is carried out by multiple examiners.

Associations Between Personality Traits And Aggression Among Malay Adult Male Inmates In Malaysia

Objective: A sizable body of criminology literature has suggested that personality factors are critical to the development of aggressive behaviour. While research on personality focusing on aggression often revolves on "Eynseck Three Factor Model" and "Big Five Model", research on "Alternative Five Factor Model" (AFFM) is rather inadequate. Objective: The present study aimed to examine the association between five types of personality traits and subscales of aggression. Methods: This observational cross-sectional study was conducted in two prisons in Peninsular Malaysia among 198 Malay adult male inmates. The participants were selected based on the purposive sampling method from those who were convicted for various types of crime. Two psychometric instruments adapted to the Malaysian context were used: Malay version of Zuckerman-Kuhlman Personality Questionnaire-40-Cross Culture (ZKPQ-M-40-CC) and Aggression Questionnaire (AQ-M). Pearson correlation coefficient test was conducted to determine the association between five types of personality traits and subscales of aggression. Results: The results showed that there was a significant association between certain types of personality traits and subscales of aggression. The results were discussed in relation to theory and the context of crime. Conclusion: There is evidence that personality traits are linked to aggressive behaviour which may lead a person to commit offenses.

Screening and detection of biomarkers in chickpea plants exposed to chromium and cadmium.

A broad screening protocol, covering the most general phytochemical groups of compounds, was developed on the basis of high performance thin layer chromatography (HPTLC). A total of six TLC systems, comprising three derivatization reagents, two stationary phases and two mobile phases, were included. The screening method was applied for the identification of biomarkers in the chickpea plant exposed to cadmium and chromium. The biomarkers were selected on the basis of significant changes (0.26-4.6 fold) in concentration levels of phytochemicals. Totally, five different amino acids, three organic acids, one sulphur containing compound and one sugar were identified as biomarkers in chickpea exposed heavy metal.

Determination of toxinotypes of environmental Clostridium perfringens by Polymerase Chain Reaction

Toxinotype of Clostridium perfringens (CP) isolates collected from the Bernam River, Selangor River and Tengi Canal between April 2007 and January 2008 were determined by Polymerase Chain Reaction (PCR) using published primers. All the 147 isolates were toxinotype Type A, harbouring the alpha toxin gene. In addition, 5 of the isolates also had the enterotoxin (CPE) gene.

Comparison of C-reactive protein among controlled, moderately controlled and uncontrolled diabetic subjects in a Bangladeshi population.

Poor glycemic control is significantly associated with the development of macrovascular complications of diabetes. C-reactive protein (CRP) is considered as a sensitive and independent risk factor for cardiovascular events. The aim of this study was to compare elevated CRP among controlled, moderately controlled and uncontrolled diabetic subjects in a Bangladeshi population. CRP and glycosylated hemoglobin A1c (HbA1c) were measured in 226 confirmed diabetic subjects purposively and randomly. Elevation of CRP in the moderately controlled (relative risk 1.64, P<0.01) and uncontrolled diabetic subjects (relative risk 1.8, P<0.001) were significantly higher than controlled diabetic subjects. HbA1c was significantly associated with the likelihood of elevated CRP in the moderately controlled diabetic subjects (OR:2.87, 95% CI: 1.41 to 5.87, P<0.01) and in the uncontrolled diabetic subjects (OR:3.83, 95% CI: 1.94 to 7.58, P<0.001). This study revealed that the likelihood of elevated CRP is associated with the increase of HbA1c in diabetic subjects.

Combining ability analysis for grain filling duration and yield traits in spring wheat (Triticum aestivum L. em. Thell.)

A diallel analysis of wheat (Triticum aestivum L. em. Thell) parents (n = 11) and their F1 (n = 55) and F2 (n = 55) offspring was carried out for the following four traits: grain filling duration (GFD), GFD for growing degree days (GDD), 1000 seed weight and seed yield per plant. Analysis of variance for general combining ability (GCA) and specific combining ability (SCA) displayed significant F1 and F2 general and specific combining ability effects for the four traits studied. For all the traits the GCA effects were relatively more important than the SCA effects, indicating that additive genetic effects were predominant. Crosses displaying high SCA effects for grain filling duration, seed weight and yield were observed to be derived from parents having various types of GCA effects (high x high, high x low, low x low and medium x low). The single seed descent method can be applied to exploit additive gene effects whereas dominance gene effects could be valuable in hybrid wheat breeding programs. Among the parents, genotypes from the International Maize and Wheat Improvement Center (Centro Internacional de Mejoramiento de Maíz y Trigo, CIMMYT) as well as South Asia were found to be superior general combiners for grain filling duration. Likewise, crosses involving diverse parents from CIMMYT and South Asia showed significant SCA effects for grain filling duration and other traits.

Zinc supplement on tissue arsenic concentration in rats.

To examine the effect of zinc in the removal of accumulated arsenic from different tissues (liver, kidneys, spleen and lungs), rats were initially allowed to drink high concentration (400 microg/kg/day) of arsenic for two months followed by a period of cessation (one month). Administration of zinc (2 mg/kg/day) during the third month in arsenic-treated and non-treated groups were compared. In arsenic-treated rats, the mean (+/- SD) amounts of total arsenic in liver, kidneys, spleen and lungs were 12.3 +/- 0.7, 20.5 +/- 1.0, 31.4 +/- 1.0 and 25.6 +/- 1.1 microg/g of tissues respectively. Administration of zinc to arsenic-treated rats reduced the arsenic concentrations of those tissues to 7.8, 10.7, 23.0 and 14.0 microg/g of tissues. This in vivo study suggests that zinc removes the accumulated arsenic from different tissues significantly (p < 0.001).